Log out. Taking Synthroid the right way In order for Synthroid to be effective, it should always be taken the same way every day. Elisa shares her journey, from getting diagnosed to starting—and continuing—treatment with Synthroid, and living with hypothyroidism. Find out what Elisa does to make sure she gets her Synthroid at the pharmacy. Elisa talks about how she takes an active role in her Synthroid treatment. Discover how Synthroid works in this short animated video.
Learn more about hypothyroidism, its causes, and risk factors from Dr. Elliot Levy. View Transcript. Take Synthroid once a day, every day at the same time before breakfast Take Synthroid with only water and on an empty stomach Wait 30 minutes to 1 hour before eating or drinking anything other than water.
TSH levels were assessed at baseline, 45, 90, and days after the start of the study. Patients reported all of their food intake at breakfast.
The average TSH at the start of the study was 1. This study shows that the absorption of levothyroxine is indeed decreased when taking the hormone with breakfast. Thus, while taking levothyroxine with breakfast could be an alternative regimen for patients who have difficulties taking the hormone on an empty stomach, this regimen is more likely to cause variability in the TSH level.
The relative amplitude and time of the nocturnal TSH surge remained intact. Moreover, Persani et al. These findings bear important practical consequences in our study as the timings for blood sampling for monitoring thyroid hormones can still be done in the morning as per present norm even if the patient is taking levothyroxine as evening dose.
Our data do not allow us to conclude that ingestion of levothyroxine 2 hours after the evening meal provides a sufficiently long interval to avoid the interfering effects of food on levothyroxine absorption. Although subjects were instructed to take their levothyroxine at least 2 hours after dinner, we did not collect data on the exact interval between dinner and levothyroxine ingestion in the bedtime-dosing subjects, and thus, we do not know if the average meal-dose interval was closer to 2, 3, or 4 hours, or longer.
From the study we inferred that there was at least similar bioavailability and metabolism of the drug either given as morning or evening dose. So in a nutshell, we can say that evening dose is as efficacious as morning dose in improvement of thyroid profile, reduction in total cholesterol levels, improvement of clinical signs and symptoms, and improvement in quality of life. In the modern busy life with hectic morning schedule, the results give hope for an alternate dosing regimen.
National Center for Biotechnology Information , U. Journal List J Thyroid Res v. J Thyroid Res. Published online Jul Author information Article notes Copyright and License information Disclaimer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Introduction Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone.
Statistical Analysis Primary end point was a change in the thyroid profile of the subjects and achievement of euthyroidism in each group measured at the end of six and 12 weeks. Observations and Results The mean age of patients in group 1 was Open in a separate window.
Discussion The present study shows noninferiority of the evening dose of levothyroxine when compared to the morning dose in terms of improvement in signs and symptoms, quality of life, and dosage of the drug required for achievement of euthyroidism.
References 1. Wiersinga WM. Subclinical hypothyroidism and hyperthyroidism. Prevalence and clinical relevance. Netherlands Journal of Medicine. The incidence of thyroid disorders in the community: a twenty year follow up of Whickham survey. Clinical Endocrinology. Replacement dose, metabolism, and bioavailability of Levothyroxine in the treatment of hypothyroidism. The New England Journal of Medicine. Sucralfate causes malabsorption of L-thyroxine. American Journal of Medicine.
Effect of calcium carbonate on the absorption of levothyroxine. Journal of the American Medical Association. Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism. Annals of Internal Medicine. Specifically, antacids , calcium , cholesterol drugs , and iron supplements can each interfere with the way the thyroid hormone is absorbed. So, you should take these particular drugs four hours before or after taking your thyroid medication, according to the U. National Library of Medicine.
Most other medication can typically be taken 45 minutes to an hour after your hypothyroidism treatment , Bianco says. Medications and Supplements to Consider and Avoid.
Some medication will affect the way your thyroid hormone is absorbed, including birth control pills , estrogen , testosterone , seizure drugs, and some depression medication , according to the American Thyroid Association ATA. Likewise, any time you stop taking these drugs or make any changes, your thyroid hormone dose may need to be adjusted, and you should see your healthcare provider then, too. Per the ATA , every brand and generic thyroid medication contains the same amount of thyroid replacement hormone.
However, many endocrinologists believe that there is a variation in hormone content among the various brands, and that there are additional factors that can interfere with how the hormone is absorbed with each one, notes the ADA.
0コメント